梁广 Liang Guang

 教授，博士生导师

 现任杭州医学院副校长，温州医科大学化学生物学研究中心主任

 曾任温州医科大学研究生院院长、药学院院长

 第四批国家万人计划科技创新领军人才

 2017年科技部中青年科技创新领军人才

 2016年国家优秀青年科学基金获得者

  2012年浙江省千人计划

中国药学会施维雅青年药物化学家奖（2015年）

 浙江省卫生高层次创新人才培养对象（2010-2015年）

 温州市2011年"580"计划人才（温州市特聘专家）

                            温州市551人才工程第一层次培养人选（2011年）

  综合运用药物化学、分子药理学、分子生物学等多学科协同创新，完成从炎症发生新机制、炎性疾病新靶点、抗炎新化合物到候选新药的转化研究。已主持国家自然科学基金7项（含重点1项、优青1项、国际合作1项）、国家科技部重点研发专项课题1项、国家863课题1项（已结题），作为通讯作者在Nat Commun、Kidney Int、J Med Chem、Diabetes等发表SCI论文100余篇，其中中科院JCR一区论文40余篇；通讯论文合计他引2000余次，单篇最高他引300余次；以第一发明人获国家发明专利授权15项；以第一完成人获2018年浙江省自然科学一等奖、2015年教育部自然科学二等奖、2011年浙江省科技进步三等奖。所研发的抗炎新化合物中，多个化合物显示出药理药代和安全性优势，成为具有优秀临床应用和开发前景的候选药物。

代表性的十篇论文

1. Shiju Ye#, Huang He#, Xue Han, Wu Luo, Lili Wu, Yang Ye, Yingchao Gong, Xia Zhao, Weijian Huang, Yi Wang, Xiaohong Long, Guosheng Fu*, Guang Liang*. Dectin-1 acts as a non-classical receptor of Ang II to induce cardiac remodeling, Circulation Research, 2023, Feb., DOI: 10.1161/CIRCRESAHA.122.322259. (一区，IF= 23.2）

2. Bozhi Ye, Hao Zhou, Yanghao Chen, Wu Luo, Wante Lin, Ying Zhao, Jibo Han, Xue Han, Weijian Huang, Gaojun Wu, Xu Wang*, Guang Liang*. USP25 Ameliorates Pathological Cardiac Hypertrophy by Stabilizing SERCA2a in Cardiomyocytes. Circulation Research, 2023, Feb 1., doi: 10.1161/CIRCRESAHA.122.321849. (一区，IF= 23.2）

3. Zheng Xu, Wu Luo, Lingfeng Chen, Zaishou Zhuang, Daona Yang, Jianchang Qian, Zia A. Khan, Xinfu Guan, Yi Wang, Xiaokun Li, Guang Liang*. Angiotensin II-induced FGFR1 activation in tubular epithelial cells promotes hypertensive kidney fibrosis and injury. Hypertension, 2022, 79:2028-41. (一区，IF= 9.90, Cover paper）

4. Wu Luo#, Ke Lin#, Junyi Hua#, Jibo Han, Qiuyan Zhang, Lingfeng Chen, Zia A. Khan, Gaojun Wu, Yi Wang, Guang Liang*. Schisandrin B attenuates diabetic cardiomyopathy by targeting MyD88 and inhibiting MyD88-dependent inflammation. Advanced Science, 2022, 9:2202590. (一区，IF= 17.5）

5. Haowen Xu, Jiahao Chen, Pan Chen, Weifeng Li, Jingjing Shao, Shanshan Hong, Yi Wang, Lingfeng Chen, Wu Luo*, Guang Liang*. Costunolide covalently targets NACHT domain of NLRP3 to inhibit inflammasome activation and alleviate NLRP3-driven inflammatory diseases. Acta Pharmaceutica Sinica B, 2022, https://doi.org/10.1016/j.apsb.2022.09.014 (一区，IF= 14.1）

6. Xu Wang, Yi Wang, Victor Antony, Hongbin Sun*, Guang Liang*. Metabolism-Associated Molecular Patterns (MAMPs). Trends in Endocrinology and Metabolism, 2020, 31(10):712-724. (一区，IF= 11.64）

7. Yi Wang#,*, Wu Luo#, Jibo Han#, Zia A. Khan, Qilu Fang, Yiyi Jin, Xuemei Chen, Yali Zhang, Meihong Wang, Jianchang Qian, Weijian Huang, Hazel Lum, Gaojun Wu, Guang Liang*. MD2 activation by direct AGE interaction drives inflammatory diabetic cardiomyopathy. Nature Communications, 2020, 11(1):2148. (一区，IF= 12.0）

8. Shiju Ye#, Wu Luo#, Zia A. Khan#, Gaojun Wu, Lina Xuan, Peiren Shan, Ke Lin, Taiwei Chen, Jingying Wang, Xiang Hu, Shengjie Wang, Weijian Huang*, Guang Liang*. Celastrol Attenuates Angiotensin II-induced Cardiac Remodeling by Targeting STAT3. Circulation Research, 2020, 126(8):1007-1023. (一区，IF= 15.862）

9. Yi Wang#, Yuanyuan Qian#, Qilu Fang#, Peng Zhong#, Weixin Li#, Lintao Wang, Weitao Fu, Yali Zhang, Zheng Xu, Xiaokun Li, Guang Liang*. Saturated palmitic acid induces myocardial inflammatory injuries through direct binding to TLR4 accessory protein MD2. Nature Communications, 2017, 8: 13997. (一区，IF= 12.124)

10. Pan Yong, Wang Yi, Zhao Yunjie, Peng Kesong, Li Weixin, Wang Yonggang, Zhang Jingjing, Zhou Shanshan, Liu Quan, Li Xiaokun, Cai Lu, Guang Liang*. Inhibition of JNK phosphorylation by a novel curcumin analog prevents high glucose-induced inflammation and apoptosis in cardiomyocytes and the development of diabetic cardiomyopathy, Diabetes, 2014, 63:3497–3511. [一区，IF=8.0]